Captain Jean-Luc Picard leads the crew of the USS Enterprise-D on its maiden voyage, to examine a new planetary station for trade with the Federation. On the way, they encounter Q, an omnipotent extra-dimensional being, who challenges Humanity as a barbaric, inferior species. Picard and his new crew must hold off Q's challenge and solve the puzzle of Farpoint station on Deneb IV, a base that is far more than it seems to be.

The crew of the Enterprise is infected with a virus that causes them to behave as though they were intoxicated.

When the leader of an alien culture takes a romantic interest in Lt. Yar, he claims her for his own, to the dismay of his own wife, who, in turn, challenges Tasha in a fight to the death.

The Enterprise is in pursuit of the Ferengi when both ships are drained of power. Picard, believing the Ferengi have initiated this energy withdrawl announces that the Enterprise is willing to resolve the situation. A mysterious being known as Portal, guardian of the Tkron Empire, appears and puts the Enterprise and the Ferengi to a test.

The Enterprise is traveling through uncharted territory when a test of the ship's engines results in a backfire that sends them a billion light years from home. They've been thrown offcourse by the mental powers of a humanoid alien posing as a propulsion assistant. The crew find themselves in an alternate reality. Their only hope is the mental powers of the alien, who is dying.

While transporting two adversary civilizations to a conference on the planet Parliament, the Enterprise passes through a "cloud" containing a series of complex energy patterns. Lt. Worf and Dr. Crusher begin behaving strangely. Suddenly the deadly force that invades them takes over the mind of Picard, and their leader as they know him is gone.

The crew is awaiting a much needed vacation on the planet of Rubicam Three. Their leave gets off to a bad start when Wesley is sentenced to death for accidentaly violating the customs of the Edo, an alien planet. Picard is forced to negociate for Wesley's life. Picard confronts the powerful and mysterious vessel the inhabitants of Edo consider to be God.

The crew of the Enterprise discovers an old-style starship. Much to Picard's delight, the ship is the Stargazer, the ship he had been forced to abandon years earlier in the battle of Maxia. The Ferengi now control the ship and say they are returning it to Starfleet. But hidden on the ship is a deadly mind-altering device designed as revenge against Picard for the death of a Ferengi captain's son. Picard becomes plagued with unexplained headaches and beams over to the Stargazer unexpectedly and raises the shields to keep others from beaming over.

While rushing to aid survivors on a planet rocked by explosions, the Enterprise is once again boarded by Q. He tempts Riker with the power of the Q, telling him he can give his friends anything they want and Picard supports the move, trusting in the honor of his crew members.

Troi's mother visits to inform her of marriage plans her late father arranged on her behalf. Honoring Betazoid customs, Deanna agrees to marry the son of her father's best friend. Wedding plans come to a halt when the groom learns that his true love is alive aboard a Tarellian ship, one of the last survivors of a biological warfare blast.

The Enterprise must pass the quadrant Korona Four, which is inhabited by the Jarada, an insect-like race that demand a precise greeting from the captain of any vessel wishing to enter their territory. Taking a break from the greeting preperations, Picard, Crusher, Data and Whalen visit 1941 San Fransico in the holodeck. The holodeck malfunctions, the four crew members are trapped in the 20th century.

The crew investigates the mysterious disappearance of an Earth colony in the Omicron Theta star system 26 years earlier, precisely the time Lt. Commander Data was discovered there. On the planet they discover a laboratory filled with android parts. When Crusher and the chief engineer assemble the parts, they bring to life a duplicate of Data, named Lore.

Seven years ago a Federation fighter was disabled on Angel One, a planet run by women. The crew discovers that all the survivors are fugitives because they refuse to support the female-run government. The Enterprise can not stay to help. A contagious virus has broken out on the ship and the Enterprise has been called to help fend off Romulans in the Neutral Zone.

The Enterprise docks at Starbase 74, where the Bynars, a species interdependent with computers, are supposed to upgrade the ships computer system. Instead of enhancing the computer, the Bynars program it to read that the ship's magnetic field is deteriorating and it will self-destruct. Unable to find Picard or Riker, Data evacuates the ship and sends it into space so it won't destroy the Starbase.

When Federation officals are taken hostage by Karnas, the govenor of Mordan IV, the Enterprise enlists the help of Admiral Mark Jameson. Jameson, at first is an old man, terminally ill. But he starts to get healthy, and younger. When confronted, he finally admits that an alien drug he took to heal his disease is rapidly de-aging him.

The Enterprise accidentlly discovers Aledea, a planet with advanced technology. It's soon discovered that the Enterprise's find was no accident. The Aldeans have lost the ability to reproduce and kidnap several children, including Wesley, from the Enterprise to repopulate their race.

At the Federation's request, the crew visits Velara III, where a group of terraformers are trying to make a desolate planet habitable. When one of the terraformers is accidently killed, Data investigates and is attacked by the same laser drilling system. He escapes injury, but discovers a small life-form that is trying to communicate with them.

The Enterprise orbits Relva 7 while Wesley Crusher beams down to take his Starfleet Academy entrance exam. Back on board Picard and his crew are quizzed by Lt. Commander Remmick who is investigating Picard's competence. During Picard's investigation he is distracted by an out-of-control shuttle, stolen by an upset student who failed his exam.

Worf's loyalties are tested to the limits as renegade Klingons who at first seem to be refugees of an unjust system of law are rescued from a doomed freighter by the Enterprise. But the survivors soon turn out to terrorists who favor a return to the Klingon ways of old and see the Enterprise as the ideal weapon with which to begin a new reign of terror.

The USS Drake has disappeared and the Enterprise has gone in search of it. When the crew arrives at the planet Minos, they are greeted by a pre-recorded sales pitch for advanced weaponry, but the crew discover there are no people to be found on the planet. An Away Team consisting of Riker, Data and Yar runs headlong into danger when Riker is put in suspended animation by an intelligent robot weapon which proved to be too powerful for its creators - and it looks as if it may eliminate the away team, joined by Picard and Dr. Crusher, while its counterpart attacks the Enterprise, where Geordi fears his experience may not be enough to help the crew survive.

The Enterprise beams four passengers of a freighter aboard just before their vessel explodes in a planet's atmosphere, but the two pairs of survivors can't agree on who gets a barrel of felicium, an "elixir" which Dr. Crusher soon recognizes to be a narcotic - but the manufacturers of the drug soon see an opportunity to exploit their dependents by entangling Picard and Dr. Crusher in the prime directive.

A malfunction causes Councelor Troi's shuttle to crash land on Varga II as she is returning to the Enterprise. The Enterprise rushes to rescue the shuttlecraft. The Away Team discovers that Armus, an evil entity, is preventing them from saving Troi and the shuttle pilot. To make sure that its point is clear, Armus kills Tasha Yar and torments Troi and the rest of the crew.

The crew experiences a bizarre phenomenon when a moment in time repeats itself. Then suddenly they recieve a distress call from Dr. Paul Manheim on Vandor Four. The crew saves Manheim and his wife, but not before they realize that his experiments have caused the time distortion and haved cracked a window into a new dimension.

Picard is taken into the confidence of his good friend Captain Walker Keel, who warns that Starfleet is slowly being taken over by a conspiracy that plans to use the resources of Starfleet for conquest. After the shocking destruction of Keel's ship and a series of grisly discoveries about the High Admirals of Starfleet, Picard learns that Earth is the home of the queen of an alien swarm.

Data, curious about three cryogenically frozen earth people from the 20th century found in a derelict preservation satellite, brings them back to the ship and Dr. Crusher revives them. Meanwhile, Picard and Riker must be prepared to negotiate or fight as the Romulans return to the borders of the neutral zone - and the 20th century visitors only complicate matters.